Permanently out of Stock: Microdosing M.ESC Drops

Important Notice: M.esc (Methalylescaline) Permanently Discontinued

As of July 1st, 2025, the sale of Methalylescaline (M.esc) has been permanently discontinued. This decision follows a legislative change passed by the Dutch Senate on June 4th, 2024, in which the phenethylamine substance group was added to List I of the Dutch Opium Act.

Methalylescaline now falls under new generic legislation that prohibits structurally similar analogues of already banned psychedelics, such as mescaline. While M.esc had been legally available for research purposes for years, it is now officially classified as an illegal substance in the Netherlands.

This legal change is part of a broader initiative by the Dutch government to curb the growing availability of new psychoactive substances (NPS). More information on this amendment is available on the official Dutch government website:
👉 Opium Act: Amendment of Substance Lists – Government.nl

We fully respect and comply with these new regulations, and have therefore permanently removed M.esc from our assortment.

permanently banned and out of stock 1-7-2025

Within the microdosing research landscape, the research molecule methallylescalin is a more recent discovery. It is found to be a suitable alternative to mescaline, the active ingredient in San Pedro Cacti.

Contents & storage:

• Methallylescaline (4-methallyloxy-3,5-dimethoxyphenethylamine)

Microdosing research with m.esc molecules

For research purposes only. Not for human consumption.*

 We do not ship this product to countries where this is a controlled substance.

Product information:

• Store in a dark and cool place (preferably refrigerator)
• Can be stored for 24 months unopened
• After opening 12 months shelf life.

Good to know

4-Metallyloxy-3,5-dimethoxyphenethylamine (also known as methallylescalin and MAL) is a legal synthetic psychedelic of the chemical class phenethylamine. It is said to have hallucinogenic and stimulant effects similar to those of mescaline when administered.

The effects of methallylescalin were first described by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. He lists the dosage range as 20mg to 40mg orally and describes the duration of action as 8 - 12 hours, whereas for microdosing research, the assumed range is between 2mg to 4mg.

 Very little data exists on the pharmacological properties, metabolism and toxicity of methallylescalin, and it has little history of human use. Thus, there’s difficulty in conducting scientific research on this analogue of mescaline in humans.

Methallylescaline, or 4-methallyloxy-3,5-dimethoxyphenethylamine, is a substituted phenethylamine with a phenyl ring bound to an amino group (NH2) via an ethyl chain. Methallylescaline contains two methoxy functional groups (CH3O-) attached to carbons R3 and R5 of the phenyl ring.

Methallylescalin is replaced by a methallyloxy chain at R4. These three carbon chains consist of an R2 methyl-substituted allyl group with a double bond on the terminal carbon. This chain is connected to the phenyl ring at R4 via an ether (oxygen) bridge.

*This statement is required by law. Research molecules such as MAL are not approved for consumption by the Commodities Act. The consumer, and no one else, is accountable and responsible for conducting research on this substance.

We do not ship this product anymore!. Out of stock! permanently banned

• United Kingdom
• Northern Ireland
• Austria
• Norway
• Germany
• Sweden
• Finland
• Denmark
• Switzerland
• Malta
• Canary Islands (Spain)
• Hungary

More info: https://psychonautwiki.org/wiki/Methallylescaline

https://www.psychedelicsdaily.com/drugs/methallylescaline/#dose-chart